Synergistic effect of naphthalenediimide and squaraine ligand targeting G-quadruplex DNA in cancer cells

方酸SQ1能够识别NDI诱导的G4平行结构，共同稳定后者，NDI促进SQ1进入和聚集在细胞核，并与SQ1共同促进细胞凋亡，产生协同效应。
Chem. Biol. Interact. 2023, 370, 110330. (DOI: 10.1016/j.cbi.2022.110330).

Chiral Naphthalenediimides with High-Efficiency Fluorescence and Circularly Polarized Luminescence in the Solid State for the Application in Organic Optoelectronics

两个NDI衍生物分子平行排列构成离散二聚体，表现出最高56.8%的荧光量子产率，该值是目前该类材料中所报道的最高值，同时具有优异的CPL特性（g值为5×10-3），打破了NDI衍生物发光效率低的固有观念。
Chem. Eur. J. 2023, 29, e202202476. (DOI: 10.1002/chem.202202476).

A naphthyridine-indole ligand for selective stabilization of G-quadruplexes and conformational conversion of hybrid topology

一种萘啶-吲哚化合物，能够诱导G四链体从杂化结构转化为平行结构，对肿瘤细胞具有显著的细胞毒性和促凋亡作用。
Bioorg. Med. Chem., 2021, 48, 116416. (DOI: 10.1016/j.bmc.2021.116416).

Chloride-promoted self-assembly and photoluminescence of naphthalenediimides tethered to polyacetylene

设计并合成了一种新型的侧链连接手性萘双亚胺（NDI）分子的聚炔。氯离子能与该聚合物特异性作用，并诱导侧链NDI从H型聚集体转变成J型聚集体，同时表现出光致发光行为。
New J. Chem., 2021, 45, 5093-5098. (DOI: 10.1039/d0nj05855f).

Topological conversion of human telomeric G-quadruplexes from hybrid to parallel form induced by naphthalene diimide ligands

在生理温度（37℃）条件下，萘双亚胺（NDI）类配体可以诱导人端粒G-四链体从杂化构型转变为平行构型，包括使用Ficoll 70 模拟的细胞内环境。NDI诱导的构型转变是一个伴随解折叠中间过渡态（如G-发卡，G-三链体等）产生的动态转变过程。
Int. J. Biol. Macromol., 2021, 167, 1048-1058. (DOI: 10.1016/j.ijbiomac.2020.11.059).

Hydrogen-bond-driven dimers of naphthyridine derivatives for selective identification of DNA G-quadruplex

设计并应用以四重氢键驱动的二聚体作为G-四链体的配体，这类配体可以使G-四链体构型发生翻转，并提高HeLa细胞内G-四链体结构稳定性，诱导细胞凋亡和细胞周期阻滞。
Org. Biomol. Chem., 2021, 19, 4768–4774 (DOI : 10.1039/D1OB00651G).

近年论文

  1. Jijun Yan, Chuanqing Kang,* Zheng Bian, Xiaoye Ma, Rizhe Jin, Zhijun Du, Lianxun Gao, An optically active polymer for broad-spectrum enantiomeric recognition of chiral acids. Chem. Eur. J. 2017, 23, 5824-5829. (DOI: 10.1002/chem.201700617)
  2. Jijun Yan, Chuanqing Kang,* Zheng Bian, Rizhe Jin, Xiaoye Ma, Zhijun Du, Haibo Yao, Lianxun Gao, Sequence-dependent self-assembly of chiral polyimides. Chem. Asian J. 2017, 12, 841-845. (DOI: 10.1002/asia.201700284)
  3. Jijun Yan, Chuanqing Kang,* Xiaoye Ma, Zhijun Du, Zheng Bian, Rizhe Jin, Lianxun Gao, Weakly basic anion recognition by naphthalenediimide-based polymer. Asian J. Org. Chem. 2017, 6, 1531-1535. (DOI: 10.1002/ajoc.201700333)
  4. Jijun Yan, Chuanqing Kang,* Zheng Bian, Rizhe Jin, Xiaoye Ma, Lianxun Gao, Supramolecular self-assembly of chiral polyimides driven by repeat units and end groups. New J. Chem. 2017, 41, 14723-14729.
  5. Qiang Wu, Lanlan Wang, Rizhe Jin, Chuanqing Kang,* Zheng Bian, Zhijun Du, Xiaoye Ma, Haiquan Guo, Lianxun Gao, Nickel-catalyzed allylic c(sp2)–h activation: stereoselective allyl isomerization and regiospecific allyl arylation of allylarenes. Eur. J. Org. Chem. 2016, 5415-5422. (DOI: 10.1002/ejoc.201600955)
  6. Lanlan Wang, Zhijun Du, Qiang Wu, Rizhe Jin, Zheng Bian, Chuanqing Kang,* Haiquan Guo, Xiaoye Ma, Lianxun Gao,* Organocatalytic enantioselective synthesis of p-stereogenic chiral oxazaphospholidines. Eur. J. Org. Chem. 2016, 2024-2028. (DOI: 10.1002/ejoc.201600100)
  7. Lanlan Wang, Shanshan Cao, Zhijun Du, Qiang Wu, Zheng Bian, Chuanqing Kang,* Lianxun Gao, Jingping Zhang, 4-Dimethylaminopyridine-catalyzed dynamic kinetic resolution in asymmetric synthesis of P-chirogenic 1,3,2-oxazaphospholidine-2-oxides. RSC Adv. 2016, 6, 89665-89670. (DOI: 10.1039/c6ra16686e)
  8. Qiang Wu, Lanlan Wang, Rizhe Jin, Chuanqing Kang,* Zheng Bian, Zhijun Du, Xiaoye Ma, Haiquan Guo, Lianxun Gao, Nickel-catalyzed allylic C(sp2)–H activation: stereoselective allyl isomerization and regiospecific allyl arylation of allylarenes. Eur. J. Org. Chem. 2016, 5415–5422. (DOI: 10.1002/ejoc.201600955)
  9. Chuanqing Kang,* Lanlan Wang, Zheng Bian, Haiquan Guo, Xiaoye Ma, Xuepeng Qiu, Lianxun Gao,* Supramolecular hydrogels derived from cyclic amino acids and their applications in the synthesis of Pt and Ir nanocrystals. Chem. Commun. 2014, 50, 13979-13982. (DOI: 10.1039/c4cc06419d)
  10. Chuanqing Kang,* Yihan Zhou, Zhijun Du, Zheng Bian, Jianwei Wang, Xuepeng Qiu, Lianxun Gao,* Yuequan Sun, Dehydrogenation and dehalogenation of amines in MALDI-TOF MS investigated by isotopic labeling. J. Mass Spectrom. 2013, 48, 1318-1324. (DOI 10.1002/jms.3296)
  11. Chuanqing Kang, Zheng Bian, Yabing He, Fushe Han, Xuepeng Qiu, Lianxun Gao, An organogel formed from a cyclic b-aminoalcohol. Chem. Commun. 2011, 47, 10746-10748. (DOI: 10.1039/c1cc13179f)
  12. Yang Xu, Chuanqing Kang,* Yu Chen, Zheng Bian, Xuepeng Qiu, Lianxun Gao,* Qingxin Meng, In situ gel-to-crystal transition and synthesis of metal nanoparticles obtained by fluorination of a cyclic b-aminoalcohol gelator. Chem. Eur. J. 2012, 18, 16955-16961. (DOI: 10.1002/chem.201202615)

专利申请和授权

  1. 金日哲，王禹，康传清，李春杰，高连勋一种表面经过修饰的磁珠及其制备方法以及定量检测相关抗原的应用. 中国发明专利，申请号CN201910604241.X，2019.7.5.
  2. 金日哲，康传清，张凤，高连勋，一种顺磁性聚合物复合微球及其制备方法，中国发明专利，申请号CN201910501095.8，2019.06.11.
  3. 金日哲，李春杰，侯靖威，孙菁，康传清，高连勋，一种顺磁性酚醛聚合物复合微球及其制备方法，中国发明专利，申请号CN201910470049.6，2019.05.31.
  4. 姚海波，郭海泉，陈文慧，杜志军，金日哲，康传清，邱雪鹏，高连勋，一种芳基嘧啶及其衍生物的制备方法，中国发明专利，授权号CN105968055B，2018.08.28.
  5. 姚海波，郭海泉，陈文慧，杜志军，金日哲，康传清，邱雪鹏，高连勋，一种芳基吡啶及其衍生物的制备方法，中国发明专利，授权号CN106220554B，2019.06.21.
  6. 康传清，吴强，金日哲，卞证，陈文慧，杜志军，马晓野，高连勋，一种1,1-二取代烯烃的制备方法，中国发明专利，授权号CN106278779B，2019.04.26.
  7. 金日哲，康传清，吴强，丁金英，邱雪鹏，高连勋，一种2,3,3’,4’-四甲基联苯的制备方法，中国发明专利，授权号CN103288583B，2016.03.23.
  8. 康传清，吴强，高连勋，金日哲，丁金英，邱雪鹏，一种四甲基联苯的制备方法，中国发明专利，授权号CN103086838B，2016.02.03.
  9. 吴强，康传清，高连勋，姚海波，丁金英，邱雪鹏，郭海泉，一种四甲基联苯的制备方法，中国发明专利，授权号CN103086837B，2016.03.23.
  10. 郭海泉，邱雪鹏，高连勋，李国民，康传清，杜志军，姚海波，丁金英，一种２，３，３′，４′－联苯四甲酸二酐制备方法，中国发明专利，授权号CN102020622B，2012.09.05.
  11. 郭海泉，邱雪鹏，康传清，杜志军，李国民，丁金英，高连勋，一种２，３，３＇，４＇－联苯二酐及其衍生物的制备方法，中国发明专利，授权号CN101481366B，2012.07.04.